Endocrine Abstracts

Introduction: Results obtained from PRIMAVERA study have demonstrated that 7.5% of obese individuals does not respond to sibutramine therapy. The aim of the study was to evaluate if GNB3, SERT, NET, TPH2 genes polymorphisms are associated with the results of obesity treatment with sibutramine.Methods: 69810 obese patients took sibutramine for at least 3 months. According to the results of 3 months therapy, we formed two groups of patients: 1) &#...